Thermo Fisher Scientific Phospho-Cyclin D1 (Thr288) Polyclonal Antibody
Cyclin D1의 Thr288 인산화 형태를 특이적으로 인식하는 Rabbit Polyclonal 항체. Western blot 및 Immunocytochemistry에 적합. 인간, 마우스, 랫트 반응성. 1 mg/mL 액상 형태로 PBS/glycerol buffer에 보존. 세포주기 연구 및 암 관련 단백질 분석에 활용 가능.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000–1:3,000 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human CCND1 (Accession P24385), corresponding to amino acid residues around phosphorylated Thr288. |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Sequential chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2817391 |
Product Specific Information
This antibody detects endogenous levels of Cyclin D1 only when phosphorylated at Thr288.
Target Information
Cyclin D1 (PRAD-1, bcl-1) is a key regulator of the cell cycle that functions with CDK4 and/or CDK6 to phosphorylate the Rb protein. It acts as a proto-oncogene and is often overexpressed in various human cancers, including mantle cell lymphoma. Cyclin D1 regulates protein phosphorylation, epithelial cell proliferation, and adipocyte differentiation. The CCND1 gene is located on chromosome 11 in humans. Cyclin D1 is synthesized during the G1 phase and forms complexes with CDK4 or CDK6 in response to growth factors, driving the G1/S transition. Its degradation is triggered by phosphorylation, leading to G1/S arrest when growth signals are absent. Mutations or overexpression of Cyclin D1 are frequently associated with tumorigenesis, making it a valuable target in cancer research and cell cycle studies.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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