Thermo Fisher Scientific Phospho-Connexin 43 (Ser373) Polyclonal Antibody
Connexin 43 단백질의 Ser373 인산화 형태를 특이적으로 인식하는 Rabbit Polyclonal 항체. Western blot 및 IHC(P) 검증 완료. 인간, 마우스, 랫트 반응성. PBS 기반 용액형으로 -20°C 보관.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000–1:3,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human GJA1 (Accession P17302), corresponding to amino acid residues around phosphorylated Ser373. |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Sequential chromatography |
| Storage buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage conditions | -20°C |
| Shipping conditions | Wet ice |
| RRID | AB_2817388 |
Product Specific Information
This antibody detects endogenous levels of Connexin 43 (GJA1) only when phosphorylated at Ser373.
Target Information
Connexin 43 (Cx43) is a member of the gap junction protein family. Connexins assemble as hexamers and are transported to the plasma membrane to form hemichannels that connect with adjacent cells to create cell-to-cell channels. These clusters form gap junctions, which are essential for intercellular communication, development, and cell growth regulation.
Phosphorylation of Cx43 regulates gap junction assembly and function. Ser368 of Cx43 is phosphorylated by protein kinase C (PKC), reducing cell-to-cell communication. Src kinase can also phosphorylate Cx43, modulating junctional communication. Connexin 43 is the major gap junction protein in the heart, playing a crucial role in synchronized contraction and embryonic development. Mutations in related genes can cause various inherited diseases.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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