Thermo Fisher Scientific Phospho-mTOR (Thr2446) Polyclonal Antibody
mTOR 단백질의 Thr2446 인산화 형태를 특이적으로 인식하는 Rabbit Polyclonal Antibody. Western blot에 적합하며, 인간, 생쥐, 랫드 시료에서 반응. 세포 성장 및 암 연구용으로 사용. 액상 형태, 1 mg/mL, -20°C 보관.
- 판매단위
- pk
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:2,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human MTOR (Accession P42345), corresponding to amino acid residues around phosphorylated Thr2446 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Sequential chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2816372 |
Product Specific Information
This antibody detects endogenous levels of mTOR only when phosphorylated at Threonine 2446.
Target Information
FRAP1 (mTOR) is a serine/threonine kinase that plays a critical role in cellular growth and proliferation. Perturbations in the mTOR/PI3-kinase/AKT pathway are associated with numerous forms of cancer. FRAP1 is also the target of rapamycin and its analogues, which are currently used as immunosuppressants and cancer therapeutics. Mutations affecting the gene result in Smith-Kingsmore syndrome.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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