Thermo Fisher Scientific CtIP Polyclonal Antibody
CtIP 단백질을 인식하는 Rabbit Polyclonal 항체로 Western blot과 Immunoprecipitation에 적합. BRCA1 상호작용 연구 및 DNA 손상 반응 연구에 유용. 액상 형태, 1 mg/mL 농도, 4°C 보관, Wet ice 배송.
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Applications
| Application | Tested Dilution / Amount |
|---|---|
| Western Blot (WB) | 1:2,000–1:10,000 |
| Immunoprecipitation (IP) | 2–10 µg/mg lysate |
Product Specifications
| 항목 | 내용 |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Region between residue 850 and the C-terminus (residue 897) of human CtBP Interacting Protein (Retinoblastoma Binding Protein 8) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Storage Conditions | 4°C |
| Shipping Conditions | Wet ice |
Product Specific Information
The recommended shelf life for this product is 1 year from the date of receipt.
Target Information
CtIP is a 125 kDa protein originally identified through its interaction with the transcriptional repressor CtBP via the PLDLS motif, suggesting a role in transcription regulation. It also interacts with BRCA1 through the C-terminal BRCT domains, indicating potential tumor suppressor functions. The CtIP–BRCA1 interaction can be disrupted by DNA-damaging agents such as UV or gamma irradiation. Li et al. (Nature 406, 210–215, 2000) demonstrated that ATM phosphorylates CtIP at serine residues 664 and 745; mutation at these sites prevents BRCA1 dissociation from CtIP, leading to persistent repression of BRCA1-dependent induction of GADD45 following ionizing radiation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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