Thermo Fisher Scientific CtIP Polyclonal Antibody
CtIP 단백질을 인식하는 Rabbit Polyclonal 항체로 Western blot 및 Immunoprecipitation에 적합. Human 및 Mouse 시료에 반응. 항원 친화 크로마토그래피로 정제되었으며, 1 mg/mL 농도의 액상 형태로 제공. 4°C에서 보관, 연구용 전용 제품.
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Applications
Western Blot (WB)
Immunoprecipitation (IP)
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Region between residue 850 and the C-terminus (residue 897) of human CtBP Interacting Protein (Retinoblastoma Binding Protein 8) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | Tris citrate/phosphate, pH 7–8 |
| Contains | 0.09% sodium azide |
| Storage Conditions | 4°C |
| Shipping Conditions | Wet ice |
Product Specific Information
The recommended shelf life for this product is 1 year from date of receipt.
Target Information
CtIP is a 125 kDa protein originally identified as interacting with the transcription repressor CtBP via the PLDLS motif, suggesting a role in transcription regulation. It also interacts with BRCA1 through the C-terminal BRCT domains, implying a potential tumor suppressor function. The CtIP–BRCA1 interaction can be disrupted by DNA damage such as UV or gamma irradiation. Studies (Li et al., Nature 406, 210–215, 2000) demonstrated that ATM phosphorylates CtIP at serine residues 664 and 745; mutation at these sites prevents BRCA1 dissociation from CtIP, leading to persistent repression of BRCA1-dependent GADD45 induction upon ionizing radiation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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