Thermo Fisher Scientific CD14 Monoclonal Antibody (OTI4H4), TrueMAB
인간 CD14 단백질을 인식하는 Mouse IgG1 단클론 항체로 Western blot과 유세포분석에 사용 가능. 고순도 친화 크로마토그래피 정제, 액상 형태로 제공되며 PBS/BSA/glycerol buffer에 보관. 연구용 전용 시약.
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Applications
Western Blot (WB)
- Tested Dilution: 1:500
Flow Cytometry (Flow)
- Tested Dilution: 1:100
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI4H4 |
| Immunogen | Human recombinant protein fragment corresponding to amino acids 20–367 of human CD14 produced in E. coli |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | −20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
CD14 is a 55 kDa GPI-anchored glycoprotein expressed on mature monocytes, macrophages, and neutrophils. It functions as a multifunctional lipopolysaccharide receptor and exists both as a membrane-bound and soluble form. CD14 binds lipopolysaccharide (LPS) in association with lipopolysaccharide-binding protein (LBP), contributing to immune response modulation. Soluble CD14 (sCD14) can distinguish structural differences between LPS molecules and plays a role in neutralizing foreign LPS in serum. Additionally, CD14 interacts with apoptotic cells and influences allergic, inflammatory, and infectious processes. Alternative splicing generates multiple transcript variants encoding the same CD14 isoform. CD14 dysfunction is associated with diseases such as Mycobacterium chelonae infection and croup.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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