Thermo Fisher Scientific CD14 Monoclonal Antibody (OTI3D6), TrueMAB
인간 CD14 단백질을 인식하는 Mouse IgG2b 단클론 항체로, Western blot과 유세포분석에 적합. 고순도 친화 크로마토그래피 정제, 액상 형태로 제공되며 안정적인 PBS/BSA/glycerol 버퍼에 보존. 연구용으로만 사용 가능.
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Applications
Western Blot (WB)
- Tested Dilution: 1:500
Flow Cytometry (Flow)
- Tested Dilution: 1:100
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2b |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI3D6 |
| Immunogen | Human recombinant protein fragment corresponding to amino acids 20–367 of human CD14 produced in E. coli |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
CD14 is a 55 kDa GPI-anchored glycoprotein expressed on the surface of mature monocytes, macrophages, and neutrophils. It functions as a multifunctional lipopolysaccharide (LPS) receptor and is released to serum as both secreted and cleaved forms. CD14 binds LPS in a reaction catalyzed by lipopolysaccharide-binding protein (LBP), aiding in neutralization of serum lipopolysaccharides. Soluble CD14 (sCD14) can discriminate structural differences between LPS molecules and participates in immune responses, including allergic, inflammatory, and infectious processes. Alternative splicing results in multiple transcript variants encoding the same isoform. CD14 dysfunction has been associated with Mycobacterium chelonae infection and croup.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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