Thermo Fisher Scientific Human Torc2 Synthetic Peptide
Human CRTC2 단백질의 C-말단 부위 16아미노산 서열 기반 합성 펩타이드. Western blot 차단 실험용으로 사용 가능하며, PA5-34547 항체와 함께 사용 시 특이적 결합 차단에 유용. PBS 기반 완충액에 0.1% BSA와 0.02% sodium azide 포함, -20°C 보관.
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Applications
Control (Ctrl)
- Assay-dependent
Blocking Assay (BLOCK)
- Assay-dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Class | Synthetic |
| Type | Peptide |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 200 µg/mL |
| Purification | Purified |
| Storage Buffer | PBS, pH 7.2, with 0.1% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
Product Specific Information
This peptide corresponds to a 16 amino acid sequence near the carboxy terminus of human CRTC2.
PEP-1590 can be used as a blocking peptide with polyclonal antibody PA5-34547.
For use as a blocking peptide in Western blot, incubate the peptide with equal volume of antibody for 30 minutes at 37°C.
Target Information
CRTC2, also known as TORC2 (Transducers Of Regulated cAMP Response Element-Binding (CREB) 2), along with the related protein CRTC1, are potent CREB coactivators exported from the nucleus in a CRM1-dependent manner via phosphorylation-dependent interactions.
Studies suggest that their phosphorylation and nuclear/cytoplasmic shuttling play an important role in the regulation of gluconeogenesis by cAMP.
CRTC2 is present in both B and T lymphocytes and is abundantly expressed in the thymus. Its activity regulates the expression of genes involved in cellular energy metabolism, while CRTC1 is essential for energy balance and fertility.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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