Thermo Fisher Scientific CD43 Recombinant Rabbit Monoclonal Antibody (PD01-28)

Applications

• Immunohistochemistry (Paraffin) (IHC (P)): Tested dilution 1:1,000

Product Specifications

Product Specific Information

• Positive control: Human B lymphocyte tumor tissue, human tonsil tissue
• Predicted band size: 40 kDa
• Subcellular Location: Membrane, microvillus, uropodium, nucleus

Target Information

CD43 (leukosialin, sialophorin) is a transmembrane mucin-like protein with a high negative charge, expressed on the surface of most hematopoietic cells. It contributes to a repulsive barrier that interferes with cellular adhesion but may also promote leukocyte aggregation in certain contexts. Through interaction with actin-binding proteins ezrin and moesin, CD43 regulates T-cell morphology and cell-cell interactions during lymphocyte traffic. CD43 signaling enhances LFA-1 adhesiveness and counteracts LFA-1 induction via other receptors. Expression of CD43 induces functionally active tumor suppressor p53 protein; however, in p53 and ARF deficiency, CD43 promotes tumor proliferation and viability. CD43 is an important modulator of leukocyte functions.
Diseases associated with CD43 dysfunction include Wiscott-Aldrich Syndrome and Adenoid Basal Cell Carcinoma.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.