Thermo Fisher Scientific alpha Synuclein Monoclonal Antibody (2B2D1, 2B2A11)
인간 알파시뉴클레인(SNCA)을 표적으로 하는 Thermo Fisher의 마우스 단클론 항체. Western blot, IHC, ELISA에 적합하며 파킨슨병 및 알츠하이머 연구에 활용 가능. 비결합형 액상 형태로 제공되며 4°C 단기, -20°C 장기 보관 권장.
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Applications and Tested Dilutions
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:500–1:2,000 | - |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:200–1:1,000 | - |
| ELISA | 1:10,000 | - |
| Miscellaneous PubMed (Misc) | - | View 1 publication |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Published Species | Not Applicable |
| Host / Isotype | Mouse / IgG |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 2B2D1, 2B2A11 |
| Immunogen | Purified recombinant fragment of SNCA expressed in E. coli |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | Not Determined |
| Storage Buffer | Ascites |
| Contains | 0.03% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term, store at -20°C. Avoid freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_10979418 |
Product Specific Information
MA5-15290 targets SNCA in indirect ELISA, immunohistochemistry, and Western blot applications, showing reactivity with human samples.
The immunogen is a purified recombinant fragment of SNCA expressed in E. coli.
Target Information
Alpha-synuclein belongs to the synuclein family, which includes beta- and gamma-synuclein. These proteins are abundant in the brain and regulate synaptic transmission and membrane trafficking.
Alpha- and beta-synuclein selectively inhibit phospholipase D2, suggesting involvement in signaling pathways.
Mutations in the SNCA gene are linked to Parkinson’s disease, and alpha-synuclein peptides are a major component of amyloid plaques in Alzheimer’s disease.
Multiple alternatively spliced transcripts encoding different isoforms of SNCA have been identified.
Diseases associated with SNCA include Parkinson Disease 1 (Autosomal Dominant) and Lewy Body Dementia.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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