Thermo Fisher Scientific Insulin Recombinant Rabbit Monoclonal Antibody (19H4L12)

Applications

Product Specifications

Product Specific Information

Intact IgG appears on a non-reducing gel as ~150 kDa band and upon reduction generates a ~25 kDa light chain band and a ~50 kDa heavy chain.

Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. These systems are developed by cloning specific antibody DNA sequences from immunoreactive rabbits. Individual clones are screened to select the best candidates for production.

Advantages of recombinant rabbit monoclonal antibodies:

• Better specificity and sensitivity
• Lot-to-lot consistency
• Animal origin-free formulations
• Broader immunoreactivity due to larger rabbit immune repertoire

Target Information

Insulin is a peptide hormone secreted by beta cells of the pancreatic islets. It regulates carbohydrate, protein, and lipid metabolism by enhancing membrane transport of glucose, amino acids, and certain ions. It promotes glycogen storage, triglyceride formation, and synthesis of proteins and nucleic acids.

Insulin is a 51-amino acid polypeptide produced from proinsulin, which is post-translationally cleaved into peptide A and peptide B, linked via two disulfide bonds and one molecule of C-peptide.

Deficiency of insulin results in diabetes mellitus, a major cause of morbidity and mortality. Insulin is also found in tumors of β-cell origin such as insulinoma.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.