Thermo Fisher Scientific CD43 Monoclonal Antibody (W3/13)

Applications and Tested Dilution

Product Specifications

Additional Formats

• PE Conjugated Format
• Request Custom Conjugation

Product Specific Information

Heat-mediated antigen retrieval is recommended for staining of paraffin sections.
For FACS analysis, use 10 µL of the suggested working dilution to label 1×10⁶ cells in 100 µL.

Target Information

CD43 (leukosialin, sialophorin) is a transmembrane mucin-like protein with a high negative charge, expressed on the surface of most hematopoietic cells.
It contributes to a repulsive barrier that interferes with cellular adhesion but can also promote leukocyte aggregation.
Through interactions with actin-binding proteins ezrin and moesin, CD43 regulates T-cell morphology and cell-cell interactions during lymphocyte traffic.
CD43 signaling enhances LFA-1 adhesiveness while counteracting LFA-1 induction via other receptors.
Expression of CD43 induces tumor suppressor p53 protein; however, in p53 and ARF deficiency, CD43 promotes tumor proliferation and viability.
CD43 is a key modulator of leukocyte functions.
Diseases associated with CD43 dysfunction include Wiscott-Aldrich Syndrome and Adenoid Basal Cell Carcinoma.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.