Thermo Fisher Scientific Human LIF Synthetic Peptide
Human LIF 단백질의 중심부 16개 아미노산 서열로 구성된 합성 펩타이드. 항체 PA5-21122의 블로킹 펩타이드로 사용 가능. 순도 높은 액상 제형으로 PBS 및 BSA 포함. 연구용으로만 사용 가능.
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Applications
Control (Ctrl)
- Assay-dependent
Blocking Assay (BLOCK)
- Assay-dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Class | Synthetic |
| Type | Peptide |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 200 µg/mL |
| Purification | Purified |
| Storage buffer | PBS, pH 7.2, with 0.1% BSA |
| Contains | 0.02% sodium azide |
| Storage conditions | -20°C |
Product Specific Information
This peptide corresponds to 16 amino acids near the center of human LIF.
PEP-1236 can be used as a blocking peptide with polyclonal antibody PA5-21122.
Target Information
Leukemia inhibitory factor (LIF) is a 20 kDa protein belonging to the IL-6 receptor family. It binds to a heterodimeric membrane receptor composed of a LIF-specific subunit (gp190 or LIFR) and gp130, which is shared with other IL-6 family members.
LIF expression has been observed in various tissues including thymus, lung, and neuronal tissue. It can be up-regulated by pro-inflammatory cytokines such as TNFα and IL-17, and elevated levels of LIF have been found in rheumatoid arthritis, neural injury, systemic inflammation, and tuberculosis.
LIF is best known for inhibiting differentiation of embryonic stem cells in mice and promoting stem cell self-renewal. Human and mouse LIF share 79% sequence homology and exhibit cross-species activity, though LIF inhibition of stem cell differentiation is mouse-specific.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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