Thermo Fisher Scientific Human ATP2C1 Synthetic Peptide
인간 ATP2C1 단백질의 C-말단 19개 아미노산 서열에 해당하는 합성 펩타이드입니다. 항체 PA5-21126의 블로킹 펩타이드로 사용 가능하며, 인간 ATP2C1 연구에 적합합니다. 정제된 액상 형태로 제공되며, PBS 버퍼 및 BSA 포함, -20°C에서 보관합니다. 연구용으로만 사용 가능합니다.
- 카탈로그번호
- PEP1240
- 카테고리
- Protein
- 판매단위
- pk
카탈로그
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Applications
Control (Ctrl)
- Assay-dependent
Blocking Assay (BLOCK)
- Assay-dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Class | Synthetic |
| Type | Peptide |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 200 µg/mL |
| Purification | Purified |
| Storage Buffer | PBS, pH 7.2, with 0.1% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
Product Specific Information
This peptide corresponds to 19 amino acids near the carboxy terminus of human ATP2C1.
PEP-1240 can be used as a blocking peptide with polyclonal antibody PA5-21126.
Target Information
ATP2C1, also known as secretory pathway Ca2+/Mn2+-ATPase (SPCA) 1, belongs to the family of P-type cation transport ATPases.
This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium from the cytosol to the Golgi lumen.
Defects in this gene cause Hailey-Hailey disease, an autosomal dominant disorder characterized by persistent blisters and erosions of the skin.
Unlike the related protein ATP2C2, ATP2C1 is ubiquitously expressed and displays a lower maximal turnover rate for overall Ca2+-ATPase reaction and a higher apparent affinity for cytosolic Ca2+ activation of phosphorylation.
Recent evidence suggests that ATP2C1 is a key regulator of insulin-like growth factor receptor (IGF1R) processing in tumor progression in basal breast cancers.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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