Thermo Fisher Scientific Human ATP2C1 Synthetic Peptide

Applications

Control (Ctrl)

• Assay-dependent

Blocking Assay (BLOCK)

• Assay-dependent

Product Specifications

Product Specific Information

This peptide corresponds to 19 amino acids near the carboxy terminus of human ATP2C1.
PEP-1240 can be used as a blocking peptide with polyclonal antibody PA5-21126.

Target Information

ATP2C1, also known as secretory pathway Ca2+/Mn2+-ATPase (SPCA) 1, belongs to the family of P-type cation transport ATPases.
This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium from the cytosol to the Golgi lumen.
Defects in this gene cause Hailey-Hailey disease, an autosomal dominant disorder characterized by persistent blisters and erosions of the skin.
Unlike the related protein ATP2C2, ATP2C1 is ubiquitously expressed and displays a lower maximal turnover rate for overall Ca2+-ATPase reaction and a higher apparent affinity for cytosolic Ca2+ activation of phosphorylation.
Recent evidence suggests that ATP2C1 is a key regulator of insulin-like growth factor receptor (IGF1R) processing in tumor progression in basal breast cancers.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.