Thermo Fisher Scientific DcR3 Polyclonal Antibody

Applications and Tested Dilution

Product Specifications

Product Specific Information

• Recommended positive control: HCT116
• Predicted reactivity: Bovine (84%)
• Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

Target Information

Apoptosis, or programmed cell death, occurs during normal cellular differentiation and development of multicellular organisms. Apoptosis is induced by certain cytokines including TNF (tumor necrosis factor) and Fas ligand of the TNF family through their death domain-containing receptors, TNFR1 and Fas. Cell death signals are transduced by death domain (DD)-containing adapter molecules and members of the ICE/CED-3 protease family.
A novel DD-containing molecule, Daxx (death associated protein 6), binds specifically to the Fas death domain, enhances Fas-induced apoptosis, and activates the Jun N-terminal kinase (JNK) pathway. Daxx is widely expressed in fetal and adult human and mouse tissues, indicating its important function in Fas signaling pathways.

Safety Information

⚠ WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.