Thermo Fisher Scientific NUP98 Polyclonal Antibody
Thermo Fisher Scientific의 NUP98 Polyclonal Antibody는 인간 NUP98 단백질을 인식하는 토끼 IgG 항체로, Western blot과 Immunoprecipitation에 최적화되어 있습니다. 항원 친화 크로마토그래피로 정제되었으며, 고농도 액상 형태로 제공되어 안정적인 장기 보관이 가능합니다.
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:3,000
Immunoprecipitation (IP)
- Tested Dilution: 1:100–1:500
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant fragment corresponding to amino acids 680–924 of NUP98 (Uniprot ID: P52948) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | 0.1M Tris Glycine, pH 7, with 20% glycerol |
| Contains | 0.01% thimerosal |
| Storage Conditions | Store at 4°C short term; for long term, store at -20°C avoiding freeze/thaw cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2552178 |
Product Specific Information
- Recommended positive controls: Jurkat, Raji
- Predicted reactivity: Mouse (98%), Rat (98%)
- IHC notes: Requires antigen retrieval using heat-mediated 10mM Citrate buffer (pH 6.0) or Tris-EDTA buffer (pH 8.0)
- Store product as a concentrated solution; centrifuge briefly prior to opening the vial
Target Information
Signal-mediated nuclear import and export occur through the nuclear pore complex (NPC), composed of ~50 unique nucleoporins. The 98 kDa nucleoporin (NUP98) is produced via proteolytic cleavage of a 186 kDa precursor, yielding both 98 kDa and 96 kDa nucleoporins localized to the nucleoplasmic side of the NPC. Studies indicate that NUP98 acts as a docking site for transport substrates.
The human NUP98 gene can fuse with other genes following chromosomal translocations in AML and T-ALL. It resides within the imprinted gene domain of 11p15.5, a key tumor-suppressor region associated with Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocortical carcinoma, and various cancers. Alternative splicing results in multiple transcript variants.
⚠ WARNING: This product can expose you to chemicals including mercury, known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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