Thermo Fisher Scientific NUP98 Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 1:500–1:3,000

Immunoprecipitation (IP)

• Tested Dilution: 1:100–1:500

Product Specifications

Product Specific Information

• Recommended positive controls: Jurkat, Raji
• Predicted reactivity: Mouse (98%), Rat (98%)
• IHC notes: Requires antigen retrieval using heat-mediated 10mM Citrate buffer (pH 6.0) or Tris-EDTA buffer (pH 8.0)
• Store product as a concentrated solution; centrifuge briefly prior to opening the vial

Target Information

Signal-mediated nuclear import and export occur through the nuclear pore complex (NPC), composed of ~50 unique nucleoporins. The 98 kDa nucleoporin (NUP98) is produced via proteolytic cleavage of a 186 kDa precursor, yielding both 98 kDa and 96 kDa nucleoporins localized to the nucleoplasmic side of the NPC. Studies indicate that NUP98 acts as a docking site for transport substrates.
The human NUP98 gene can fuse with other genes following chromosomal translocations in AML and T-ALL. It resides within the imprinted gene domain of 11p15.5, a key tumor-suppressor region associated with Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocortical carcinoma, and various cancers. Alternative splicing results in multiple transcript variants.

⚠ WARNING: This product can expose you to chemicals including mercury, known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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