Thermo Fisher Scientific mPR gamma Polyclonal Antibody

Applications

• Western Blot (WB): 1:500–1:1,000

Product Specifications

Product Specific Information

• Detects endogenous protein at a molecular weight of 38 kDa.
• Purity is >95% by SDS-PAGE.

Target Information

The steroid progesterone induces the resumption of maturation in oocytes via a nongenomic pathway through binding to a novel, membrane progestin receptor (mPR). This pathway inhibits adenylyl cyclase and reduces intracellular cAMP, and also activates mitogen-activated protein kinase to effect signal transduction pathways.
Three distinct groups, designated alpha, beta, and gamma, comprise this gene family. While all contain 7 transmembrane domains, they show distinct distributions in reproductive, neural, kidney, and intestinal tissues. These characteristics separate them from nuclear progestin receptors and imply similarity to G-protein coupled receptors.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.