Thermo Fisher Scientific MUPP1 Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 1:2,000–1:10,000

Immunoprecipitation (IP)

• Tested Dilution: 2–5 µg/mg lysate

Product Specifications

Product Specific Information

• Recommended shelf life: 1 year from date of receipt
• Based on 100% sequence identity, this antibody is predicted to react with Mouse and Rat

Target Information

MUPP1 (multi PDZ domain protein 1, MPDZ) was discovered as an interacting partner with the 5-HT2C receptor, and was found to co-localize with 5-HT2A or 5-HT2C receptors in all regions of the mouse brain, including the choroid plexus.
MUPP1 contains 13 PDZ domains but no apparent catalytic domain. It is concentrated in tight junctions of polarized epithelial cells and binds to claudin-1 and junctional adhesion molecule (JAM).
MUPP1 may function as a multivalent scaffold protein that recruits various proteins to tight junctions. It also interacts with claudin-8 and may play a role in tight junction barrier function.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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