Thermo Fisher Scientific NS1-BP Polyclonal Antibody
Human NS1-Binding Protein을 타겟으로 하는 Rabbit Polyclonal Antibody로 Western Blot 및 Immunoprecipitation에 적합. 항원 친화 크로마토그래피로 정제된 액상 형태이며, 1 mg/mL 농도 유지. 세포 내 actin 구조 및 AHR 경로 연구용으로 권장.
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Applications
Western Blot (WB)
- Tested Dilution: 1:2,000–1:10,000
Immunoprecipitation (IP)
- Tested Dilution: 2–5 µg/mg lysate
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Region between residue 50 and 100 of human NS1-Binding Protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | Phosphate/Tris citrate, pH 7–8 |
| Contains | 0.09% sodium azide |
| Storage Conditions | 4°C |
| Shipping Conditions | Wet ice |
Product Specific Information
The recommended shelf life for this product is 1 year from date of receipt.
Target Information
IVNS1ABP is a protein-coding gene involved in various cellular functions, including:
- Pre-mRNA splicing
- Aryl hydrocarbon receptor (AHR) pathway
- F-actin organization and protein ubiquitination
It stabilizes actin filaments through association with F-actin via Kelch repeats and protects cells from actin destabilization-induced death.
Acts as a modifier of the AHR pathway, increasing AHR concentration for transcription activation.
Functions as a negative regulator of the BCR(KLHL20) E3 ubiquitin ligase complex, preventing ubiquitin-mediated proteolysis of PML and DAPK1, two tumor suppressors.
Also inhibits pre-mRNA splicing in vitro.
During microbial infection, it participates in the alternative splicing of influenza A virus M1 mRNA via interaction with HNRNPK, aiding M2 protein generation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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