
Thermo Fisher Scientific M-cadherin Polyclonal Antibody
Thermo Fisher Scientific의 M-cadherin Polyclonal Antibody는 근육 세포 분화 연구용 항체입니다. Western blot, IHC, ELISA에 사용 가능하며, 토끼 유래 IgG 형식의 비결합 항체입니다. 인간 시료에 검증되었으며, -20°C에서 보관합니다.
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Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | Assay-dependent | - |
| Immunohistochemistry (IHC) | - | View 1 publication |
| ELISA | Assay-dependent | - |
Product Specifications
| 항목 | 내용 |
|---|---|
| Published species | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide derived from the C-terminal region of the mouse M-Cadherin (Cadherin 14, Cadherin 15) protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.25 mg/mL |
| Storage conditions | -20°C |
| Shipping conditions | Wet ice |
| RRID | AB_2533245 |
Target Information
Cadherins are a multigene family of Ca++-dependent cell adhesion molecules. They are transmembrane glycoproteins consisting of an extracellular domain, which mediates Ca++-dependent intercellular adhesion by homophilic interactions, a transmembrane region, and a cytoplasmic domain. The extracellular domain is divided into subdomains EC1–EC5. Homologies among cadherins are most prominent in the cytoplasmic domain and EC1–EC2 regions, and less so in EC5 or the transmembrane region. The adhesive function is primarily determined by the N-terminal portion of the molecule.
Four major cadherins—neuronal (N), epithelial (E), placental (P), and muscle (M)—have been identified in mammalian cells. M-cadherin is not expressed in fibroblasts but is present at low levels in myoblasts and is upregulated during myotube formation, indicating its role in skeletal muscle cell differentiation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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