Thermo Fisher Scientific Furin Polyclonal Antibody
Furin 단백질을 인식하는 Rabbit Polyclonal Antibody로, WB, IHC, ICC/IF, ELISA 등 다양한 응용에 사용 가능. Human, Mouse, Non-human primate 시료에 적합하며, 액상 형태로 -20°C 보관. 연구용으로만 사용.
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Applications
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | Assay-dependent | View 2 publications |
| Immunohistochemistry (IHC) | - | View 1 publication |
| Immunocytochemistry (ICC/IF) | - | View 1 publication |
| ELISA | Assay-dependent | View publications |
Product Specifications
| Specification | Description |
|---|---|
| Published species | Human, Mouse, Non-human primate |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide derived from the mid region of the human Furin protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.25 mg/mL |
| Storage conditions | -20°C |
| Shipping conditions | Wet ice |
| RRID | AB_2533242 |
Target Information
Furin is a membrane-associated, calcium-dependent serine protease belonging to the subtilisin-like prohormone convertase (PC) family. This family cleaves most prohormones and neuropeptide precursors, as well as various cellular, viral, and bacterial proteins transported via the constitutive secretory pathway.
Furin and other PCs share structural similarities:
- ~10 kDa amino-terminal proregion
- ~55 kDa conserved subtilisin-like catalytic domain
- Variable carboxyl-terminal domain
These enzymes become active after proregion cleavage within the correct cellular compartment. Furin is unique among PCs in possessing a transmembrane domain. Cleavage occurs at the carboxyl-terminus of the consensus sequence RX(K/R)R.
The acidic peptide sequence C771PSDSEEDEG780 localizes furin to the trans-Golgi network, and phosphorylation of serine residues in this region modulates intracellular routing. The tetrapeptide sequence Y759KGL762 directs internalization from the cell surface.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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