Thermo Fisher Scientific CCBE1 Polyclonal Antibody
CCBE1 단백질을 인식하는 Rabbit Polyclonal 항체로 Western blot에 적합. Human, Mouse, Rat 시료에 반응하며, 항원 친화 크로마토그래피로 정제됨. 액상 형태로 1 mg/mL 농도, PBS(glycerol 포함) 완충액에 보관. 단백질 분자량 44 kDa 검출.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic peptide corresponding to residues in human CCBE1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2553979 |
Product Specific Information
- This antibody detects endogenous CCBE1 protein at a molecular weight of approximately 44 kDa.
- Purity is >95% by SDS-PAGE.
Target Information
The CCBE1 gene (Collagen and calcium-binding EGF domain-containing protein 1) is located on chromosome 18, a region frequently deleted in breast and prostate cancers.
CCBE1 encodes a 406 amino acid secreted protein containing two collagen-like domains and one calcium-binding EGF-like domain.
EGF-like domains typically include six cysteine residues involved in disulfide bonds. Calcium-binding EGF-like domains are sensitive to amino acid substitutions that can alter protein structure or calcium affinity, thereby affecting function.
Downregulation of CCBE1 is commonly observed in breast cancer, suggesting its loss may influence cell adhesion and motility due to its extracellular nature.
Three isoforms of CCBE1 are produced through alternative splicing events.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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