Thermo Fisher Scientific CD44 Monoclonal Antibody (OTI1G8), TrueMAB

Applications

ELISA (ELISA)

• Tested Dilution: 1:100 - 1:1,000

Luminex (LUM)

• Tested Dilution: Assay-Dependent

Product Specifications

Target Information

CD44 cell surface antigen is a 100 kDa type 1 transmembrane glycoprotein widely expressed on human leukocytes, white matter of the brain, and some epithelial cells of the intestine and breast. Several isoforms of CD44 exist, including the predominant CD44H isoform detected in many normal tissues.
CD44 acts as a receptor for hyaluronic acid (HA) and is involved in cell-cell interactions, adhesion, and migration. It participates in lymphocyte activation, recirculation, and homing.
CD44 expression may be up-regulated in certain carcinomas, potentially related to metastatic potential. It is expressed in hematopoietic and non-hematopoietic cells, epithelial tissues, and filopodia of cultured keratinocytes.
Bone marrow myeloid cells and memory T cells express CD44 at high levels, and peripheral B and T cells can upregulate CD44 expression in response to stimulation.
Transcripts undergo complex alternative splicing, producing functionally distinct isoforms. Diseases associated with CD44 dysfunction include superficial keratitis and lichen sclerosus. CD44 may also be related to tumor metastasis formation.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.