Thermo Fisher Scientific CD44 Monoclonal Antibody (OTI1G1), TrueMAB

Applications

ELISA (ELISA)

• Tested Dilution: 1:100 - 1:1,000

Luminex (LUM)

• Tested Dilution: Assay-Dependent

Product Specifications

Target Information

CD44 cell surface antigen is a 100 kDa type 1 transmembrane glycoprotein widely expressed on human leucocytes, white matter of the brain, and by some epithelial cells of the intestine and breast. Several isoforms of CD44 exist, including the predominant CD44H isoform detected in many normal tissues. CD44 is a receptor for hyaluronic acid (HA) and is involved in cell-cell interactions, cell adhesion, and migration. It participates in various cellular functions such as lymphocyte activation, recirculation, and homing. CD44 expression may be up-regulated upon some carcinomas and may be related to metastatic potential. CD44 is expressed by hematopoietic and non-hematopoietic cells, epithelial tissues, and filopodia in cultured keratinocytes. Bone marrow myeloid cells and memory T cells express CD44 at high levels, and peripheral B and T cells can upregulate its expression in response to stimulatory events. Transcripts for the CD44 gene undergo complex alternative splicing, resulting in many functionally distinct isoforms. Alternative splicing is the basis for the structural and functional diversity of the CD44 protein. Diseases associated with CD44 dysfunction include superficial keratitis and lichen sclerosus. CD44 also may be related to tumor metastasis formation.

For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.