Thermo Fisher Scientific IL10RA Polyclonal Antibody
IL10RA 단백질을 인식하는 Rabbit Polyclonal 항체로, Western blot, IHC, ICC/IF 등 다양한 응용에 적합. Human 시료 반응성. Affinity chromatography로 정제되어 높은 특이성과 재현성 제공. 4°C 단기 보관, -20°C 장기 보관 권장.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:200–1:1,000 |
| Immunocytochemistry (ICC/IF) | 1:50–1:200 |
Product Specifications
| Specification | Details |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide within human IL-10RA aa 491–540/578 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 40% glycerol, 0.05% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2913467 |
Product Specific Information
- Positive Control: Daudi cell lysates, Jurkat cell lysate, THP-1 cell lysate, MCF-7 cell lysate, human tonsil tissue, SiHa
- Subcellular Location: Cytoplasm, Cell membrane
Target Information
The IL10RA gene encodes a receptor for interleukin 10, structurally related to interferon receptors. It mediates the immunosuppressive signal of interleukin 10, inhibiting synthesis of proinflammatory cytokines. This receptor promotes survival of progenitor myeloid cells through the insulin receptor substrate-2/PI 3-kinase/AKT pathway. Activation leads to tyrosine phosphorylation of JAK1 and TYK2 kinases. Two transcript variants have been identified, one protein-coding and one non-coding.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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