Thermo Fisher Scientific Phospho-MSK1 (Ser376) Polyclonal Antibody
MSK1 단백질의 Ser376 인산화 형태를 인식하는 Rabbit Polyclonal Antibody. Western blot 검증 완료. 인간, 생쥐, 랫드 반응성. 항원 친화 크로마토그래피로 정제된 액상 형태. 연구용으로만 사용 가능.
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Applications
Western Blot (WB)
- Tested Dilution: 1:1,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic phosphopeptide corresponding to residues surrounding pSer376 of human MSK1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Purification | Antigen affinity chromatography |
| Storage buffer | 0.01M HEPES, pH 7.5, with 0.15M NaCl, 100µg/mL BSA, 50% glycerol |
| Contains | No preservative |
| Storage conditions | -20°C |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_10980557 |
Product Specific Information
It is not recommended to aliquot this antibody.
Target Information
RPS6KA5 (MSK1) is a serine/threonine protein kinase essential for regulating various cellular processes. It mediates mitogen or stress-induced phosphorylation of transcription factors such as CREB1, ATF1, RELA, STAT3, and ETV1/ER81. MSK1 contributes to gene activation via histone phosphorylation and regulates inflammatory gene expression. It phosphorylates CREB1 and ATF1 in response to stimuli such as UV-C irradiation, EGF, and anisomycin. MSK1 also modulates RELA transcriptional activity upon TNF stimulation and interacts with the glucocorticoid receptor NR3C1 to repress inflammatory gene expression. In skeletal myoblasts, it phosphorylates RELA at Ser-276 during oxidative stress, and in erythropoietin-stimulated cells, it is required for Ser-727 phosphorylation of STAT3.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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