Thermo Fisher Scientific CD200 Receptor Monoclonal Antibody (OX110), PE, eBioscience
마우스 CD200R(OX2) 인식용 OX110 단클론 항체로, PE 형광표지되어 흐름세포분석(Flow Cytometry)에 적합합니다. 0.25 µg/test로 사용되며, 565/576 nm에서 여기/방출. 혈액세포 및 면역세포 분석 연구용으로 최적화된 항체입니다.
- 카탈로그번호
- 12-5201-8x (2개 옵션)
- 판매단위
- pk
카탈로그
2개 옵션 · 카탈로그 번호를 클릭하면 복사됩니다Thermo Fisher Scientific · Thermo Fisher Scientific CD200 Receptor Monoclonal Antibody (OX110), PE, eBioscience
Thermo Fisher Scientific CD200 Receptor Monoclonal Antibody (OX110), PE, eBioscience
Applications
- Flow Cytometry (Flow)
Tested Dilution
- 0.25 µg/test
Publications
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Mouse |
| Published Species | Mouse |
| Host / Isotype | Rat / IgG2a, kappa |
| Recommended Isotype Control | Rat IgG2a kappa Isotype Control (eBR2a), PE, eBioscience™ |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OX110 |
| Conjugate | PE |
| Excitation / Emission Max | 565 / 576 nm |
| Form | Liquid |
| Concentration | 0.2 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.2 |
| Contains | 0.09% sodium azide |
| Storage Conditions | 4°C, store in dark, DO NOT FREEZE! |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_1582265 |
Additional Formats
Product Specific Information
Description:
The monoclonal antibody OX110 recognizes mouse CD200R, also known as OX2. CD200R is an inhibitory receptor structurally similar to its ligand CD200 but lacks an ITIM domain. Its cytoplasmic domain contains a phosphotyrosine binding domain (NPXY), which binds SHIP and inhibits ERK, JNK, and MAPK p38 pathways, leading to reduced TNF-alpha secretion in activated macrophages.
Expression:
CD200R expression is restricted to hematopoietic cells including myeloid cells (monocytes, macrophages, DCs, neutrophils, mast cells, basophils) and subsets of lymphocytes, as well as Langerhans cells and dendritic epidermal T cells.
Applications Reported:
- Flow cytometric analysis.
Applications Tested:
- Tested by flow cytometric analysis of mouse thioglycolate-elicited peritoneal exudate cells.
- Recommended ≤ 0.25 µg/test (100 µL final volume).
- Optimal titration required for specific assay conditions.
- Suitable for analysis using Blue, Green, or Yellow-Green lasers (Excitation: 488–561 nm; Emission: 578 nm).
- 0.2 µm post-manufacturing filtration.
Target Information
CD200R (OX2R):
CD200R is a receptor for the OX-2 membrane glycoprotein. Both receptor and ligand are surface glycoproteins with two immunoglobulin-like domains. CD200R is mainly found on myeloid lineage cells and mediates downregulatory signaling. In mice, it is primarily expressed on monocytes and neutrophils, but also on T-lymphocytes and mast cells. Alternative splicing of CD200R produces multiple transcript variants. Dysfunction of CD200R has been linked to primary hypertrophic osteoarthropathy.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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