Thermo Fisher Scientific MST1 (STK4) Monoclonal Antibody (07)

Applications

• ELISA (ELISA): 1:250–1:2,000 dilution tested

Product Specifications

Product Specific Information

This product is preservative-free. It is recommended to add sodium azide to avoid contamination (final concentration 0.05%–0.1%).
This antibody has specificity for Human STK4/MST1.

Target Information

STK4 (MST1) is a serine/threonine kinase involved in apoptosis. It induces chromatin condensation during apoptosis and acts as a stress-activated, pro-apoptotic kinase. Upon caspase cleavage, STK4 enters the nucleus, inducing chromatin condensation and DNA fragmentation.

STK4 is a key component of the Hippo signaling pathway, which regulates organ size and tumor suppression by restricting proliferation and promoting apoptosis.
In this pathway, STK3/MST2 and STK4/MST1 (in complex with SAV1) phosphorylate and activate LATS1/2 (in complex with MOB1), which then phosphorylate and inactivate YAP1 and WWTR1/TAZ.
Phosphorylation of YAP1 prevents its nuclear translocation, thereby regulating genes involved in cell proliferation, death, and migration.
STK3/MST2 and STK4/MST1 are required to repress hepatocyte proliferation, prevent activation of adult liver stem cells, and inhibit tumor formation.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.