Thermo Fisher Scientific Tyrosine Hydroxylase Recombinant Rabbit Monoclonal Antibody (001)

Applications and Tested Dilutions

Product Specifications

Product Specific Information

This antibody is preservative-free. It is recommended to add sodium azide to prevent contamination (final concentration 0.05%–0.1%).

Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems developed by cloning antibody DNA sequences from immunoreactive rabbits. Individual clones are screened to select optimal candidates for production.

Advantages:

• High specificity and sensitivity
• Lot-to-lot consistency
• Animal origin-free formulation
• Broad immunoreactivity due to the rabbit immune repertoire

This antibody specifically recognizes Mouse TH/Tyrosine Hydroxylase.

Target Information

Tyrosine hydroxylase (TH) is a key enzyme in the synthesis of catecholamine neurotransmitters—dopamine, epinephrine, and norepinephrine. Catecholamine synthesis is regulated by the interaction of TH with the cofactor tetrahydrobiopterin (BH4), which binds to the TH catalytic domain to activate the enzyme.

In humans, four TH mRNA splice variants (hTH1–hTH4) have been identified, differing in their N-terminal regulatory domains but sharing identical catalytic domains. TH catalyzes the conversion of L-tyrosine to L-DOPA and plays a central role in adrenergic neuron physiology.

Alterations in TH function are associated with several neuropathogenic and cardiovascular diseases, including:

• Parkinson’s disease
• Schizophrenia
• Segawa syndrome
• Dystonia

For Research Use Only. Not for use in diagnostic procedures or resale without authorization.