Thermo Fisher Scientific Dectin 1 (soluble) Polyclonal Antibody
Thermo Fisher Scientific의 Dectin 1 (soluble) Polyclonal Antibody는 인간 CLEC7A 단백질을 인식하는 토끼 다클론 항체입니다. Western blot과 ICC/IF에 적합하며, 항원 친화 크로마토그래피로 정제되었습니다. PBS, 40% 글리세롤 보존액에 0.02% sodium azide를 포함하며 4°C 또는 -20°C에서 보관합니다.
- 카탈로그번호
- PA583996
- 판매단위
- pk
카탈로그
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 0.04–0.4 µg/mL |
| Immunocytochemistry (ICC/IF) | 0.25–2 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human CLEC7A. Recombinant protein control fragment (Product #RP-104894). |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.05 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2791148 |
Product Specific Information
Immunogen sequence:
DSSNELGFIV KQVSSQPDNS FWIGLSRPQT EVPWLWEDGS TFSSNLFQIR TTATQENPSP NCVWIHVSVI YDQLCSVPSY SICEKKFS
Target Information
CLEC7A, also known as dectin-1, is a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily and is predominantly expressed on myeloid cells. It is a small glycoprotein type II membrane receptor with an extracellular C-type lectin-like domain fold and a cytoplasmic domain with an immunoreceptor tyrosine-based activation motif (ITAM).
CLEC7A functions as a pattern-recognition receptor that recognizes a variety of beta-1,3-linked and beta-1,6-linked glucans from fungi and plants, and in this way plays a role in innate immune response. Upon fungal exposure, CLEC7A activates Syk tyrosine kinase, triggering a massive oxidative burst through the formation of reactive oxygen species.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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