Thermo Fisher Scientific CTLA-4 Recombinant Rabbit Monoclonal Antibody (11H7L17)
Human CTLA-4 단백질에 특이적인 재조합 토끼 단클론 항체. ICC/IF에 2 µg/mL로 사용 가능. Expi293 시스템에서 발현된 IgG 항체로 우수한 특이성과 재현성을 제공. 단기 4°C, 장기 -20°C 보관 권장.
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Applications
Immunocytochemistry (ICC/IF)
- Tested Dilution: 2 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Expression System | Expi293 |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | 11H7L17 |
| Immunogen | Protein corresponding to human CTLA4 (aa186–223) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS, pH 7.4 |
| Contains | 0.09% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2662598 |
Product Specific Information
- This antibody is predicted to react with Monkey, Cat, and Pig.
- Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems developed by cloning specific antibody DNA sequences from immunoreactive rabbits.
- Individual clones are screened to select the best candidates for production.
- Advantages include:
- Improved specificity and sensitivity
- Lot-to-lot consistency
- Animal origin-free formulation
- Broader immunoreactivity to diverse targets due to the larger rabbit immune repertoire
Target Information
CTLA4 (Cytotoxic T-Lymphocyte Antigen 4) is a CD28-family receptor expressed mainly on CD4+ T cells. It binds the same ligands as CD28 (CD80 and CD86 on B cells and dendritic cells) but with higher affinity. Unlike CD28, which enhances T cell activation, CTLA4 inhibits T cell function. Intracellular CTLA4 is also found in regulatory T cells and is important for their suppressive activity.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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