Thermo Fisher Scientific CTLA-4 Recombinant Rabbit Monoclonal Antibody (11H7L17)

Applications

Immunocytochemistry (ICC/IF)

• Tested Dilution: 2 µg/mL

Product Specifications

Product Specific Information

• This antibody is predicted to react with Monkey, Cat, and Pig.
• Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems developed by cloning specific antibody DNA sequences from immunoreactive rabbits.
• Individual clones are screened to select the best candidates for production.
• Advantages include:
  • Improved specificity and sensitivity
  • Lot-to-lot consistency
  • Animal origin-free formulation
  • Broader immunoreactivity to diverse targets due to the larger rabbit immune repertoire

Target Information

CTLA4 (Cytotoxic T-Lymphocyte Antigen 4) is a CD28-family receptor expressed mainly on CD4+ T cells. It binds the same ligands as CD28 (CD80 and CD86 on B cells and dendritic cells) but with higher affinity. Unlike CD28, which enhances T cell activation, CTLA4 inhibits T cell function. Intracellular CTLA4 is also found in regulatory T cells and is important for their suppressive activity.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.