Thermo Fisher Scientific Pan TEF1 Recombinant Rabbit Monoclonal Antibody (ARC1158)
Recombinant rabbit monoclonal antibody against human TEF1 (clone ARC1158). Suitable for WB and ELISA. High purity via affinity chromatography. Supplied in PBS buffer with glycerol and BSA. For research use only.
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Applications
Western Blot (WB)
- Tested Dilution: 1:1,000–1:5,000
ELISA
- Tested Concentration: 1 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | ARC1158 |
| Immunogen | Recombinant fusion protein containing a sequence corresponding to amino acids 174–263 of human TEAD4 (NP_0032042) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 2.5 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 50% glycerol, 0.05% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2849538 |
Product Specific Information
Immunogen sequence:
SHDVKPFSQQ TYAVQPPLPL PGFESPAGPA PSPSAPPAPP WQGRSVASSK LWMLEFSAFL EQQQDPDTYN KHLFVHIGQS SPSYSDPYLE
Target Information
TEF1 (Transcriptional enhancer factor 1), a member of the TEA/ATTS domain family, is a nuclear protein expressed in numerous cell types and plays a role in controlling gene expression. TEF family members possess a highly conserved DNA-binding domain. TEF-1 binds to GT-IIC, SphI/II, and M-CAT sites, and to the proximal regulatory element (PRE) of transforming growth factor-alpha, which is overexpressed in various cancers. TEF-1 represses transcription in placental cells and is phosphorylated by PKC isozymes, both in vivo and in vitro, reducing its DNA-binding capability. This suggests a potential role in PKC inhibition and tumorigenesis. Dimerization of TEF-1 may be essential for its function as a transcription regulator.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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