Thermo Fisher Scientific GATA2/GATA3 Recombinant Rabbit Monoclonal Antibody (ARC1209)

Applications and Tested Dilution

Product Specifications

Product Specific Information

Immunogen sequence:
MEVAPEQPRW MAHPAVLNAQ HPDSHHPGLA HNYMEPAQLL PPDEVDVFFN HLDSQGNPYY ANPAHARARV SYSPAHARLT GGQMCRPHLL HSPGLPWLDG GKAALSAAAA HHHNPWTVSP FSKTPLHPSA AGGPGGPLSV YPGAGGGSGG GSGSSVASLT PTAAHSGSHL FGFPPTPPKE VSPDPSTTGA ASPASSSAGG SAARGEDKDG

Target Information

The genes for all four subunits of the T-cell antigen receptor (alpha, beta, gamma, and delta) are controlled by distinct enhancers and their enhancer-binding proteins.
Marine and Winoto (1991) identified a common TCR regulatory element by demonstrating binding of the enhancer-binding protein GATA3 to the enhancer elements of all four TCR genes. GATA3 had been shown in chicken to be an enhancer-binding protein containing a zinc finger domain.

GATA3 mRNA was demonstrated by Northern blot analysis in T cells but not in B cells or macrophages. It is abundantly expressed in the T-lymphocyte lineage and is thought to participate in T-cell receptor gene activation through enhancer binding.
Labastie et al. (1994) cloned the human gene and the 5′ end of the mouse gene. The human gene comprises six exons distributed over 17 kb of DNA, with its two zinc fingers encoded by separate exons highly conserved with those of GATA1.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.