Thermo Fisher Scientific ARHGEF3 Polyclonal Antibody
Rabbit polyclonal antibody targeting human ARHGEF3 protein. Validated for IHC (Paraffin) with dilution 1:25–1:100. Detects endogenous ARHGEF3 involved in Rho GTPase signaling and bone cell biology. Supplied as unconjugated liquid, 0.9 mg/mL, stored at ...
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Applications
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:25–1:100
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Fusion protein corresponding to residues near the N-terminal of human Rho guanine nucleotide exchange factor (GEF) 3 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.9 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 40% glycerol |
| Contains | 0.05% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2635785 |
Product Specific Information
The antibody detects endogenous levels of total ARHGEF3 protein.
Target Information
Rho-like GTPases are involved in various cellular processes, activated by GTP binding and inactivated by GTP hydrolysis. Guanine nucleotide exchange factors (GEFs) promote activation by facilitating GDP release.
ARHGEF3 specifically activates RHOA and RHOB, both important in bone cell biology. Genetic variations in ARHGEF3 are associated with bone mineral density (BMD) and postmenopausal osteoporosis.
Alternatively spliced transcript variants encoding different isoforms have been identified.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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