Thermo Fisher Scientific IDH3B Polyclonal Antibody

Thermo Fisher Scientific IDH3B Polyclonal Antibody

Applications and Tested Dilution

• Western Blot (WB): 1:200–1:1,000
• Immunohistochemistry (Paraffin) (IHC (P)): 1:25–1:100

Product Specifications

Product Specific Information

This antibody detects endogenous levels of total IDH3B protein.

Target Information

Isocitrate dehydrogenases catalyze the oxidative decarboxylation of isocitrate to 2-oxoglutarate. These enzymes belong to two distinct subclasses, one utilizing NAD(+) and the other NADP(+) as electron acceptors.
Five isocitrate dehydrogenases have been reported: three NAD(+)-dependent (mitochondrial matrix localized) and two NADP(+)-dependent (one mitochondrial, one cytosolic).
NAD(+)-dependent isocitrate dehydrogenases catalyze the allosterically regulated rate-limiting step of the tricarboxylic acid cycle.
Each isozyme is a heterotetramer composed of two alpha subunits, one beta subunit, and one gamma subunit.
The protein encoded by this gene is the beta subunit of an NAD(+)-dependent isocitrate dehydrogenase isozyme. Three alternatively spliced transcript variants encoding different isoforms have been described.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

제품 이미지

(이미지 없음 – OCR 텍스트는 본문에 통합됨)