Thermo Fisher Scientific IDH3B Polyclonal Antibody
IDH3B 단백질을 인식하는 Thermo Fisher Scientific의 다클론 항체. Western blot 및 IHC(P) 실험에 적합. 인간과 생쥐 반응성, 항원 친화 크로마토그래피로 정제. 액상 형태로 제공되며 -20°C 보관.
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- PA550337
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Thermo Fisher Scientific IDH3B Polyclonal Antibody
Applications and Tested Dilution
- Western Blot (WB): 1:200–1:1,000
- Immunohistochemistry (Paraffin) (IHC (P)): 1:25–1:100
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Fusion protein corresponding to residues near the C-terminal of human isocitrate dehydrogenase 3 (NAD+) gamma |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1.2 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 40% glycerol |
| Contains | 0.05% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2635790 |
Product Specific Information
This antibody detects endogenous levels of total IDH3B protein.
Target Information
Isocitrate dehydrogenases catalyze the oxidative decarboxylation of isocitrate to 2-oxoglutarate. These enzymes belong to two distinct subclasses, one utilizing NAD(+) and the other NADP(+) as electron acceptors.
Five isocitrate dehydrogenases have been reported: three NAD(+)-dependent (mitochondrial matrix localized) and two NADP(+)-dependent (one mitochondrial, one cytosolic).
NAD(+)-dependent isocitrate dehydrogenases catalyze the allosterically regulated rate-limiting step of the tricarboxylic acid cycle.
Each isozyme is a heterotetramer composed of two alpha subunits, one beta subunit, and one gamma subunit.
The protein encoded by this gene is the beta subunit of an NAD(+)-dependent isocitrate dehydrogenase isozyme. Three alternatively spliced transcript variants encoding different isoforms have been described.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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