Thermo Fisher Scientific IDH3B Polyclonal Antibody
IDH3B 단백질을 검출하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody. Western blot과 IHC(Paraffin) 분석에 적합하며, 인간 및 생쥐 시료 반응. 항원 친화 크로마토그래피로 정제된 고품질 항체로 연구용으로 사용.
- 카탈로그번호
- PA550336
- 판매단위
- pk
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Thermo Fisher Scientific IDH3B Polyclonal Antibody
Applications and Tested Dilution
- Western Blot (WB): 1:200–1:1,000
- Immunohistochemistry (Paraffin) (IHC (P)): 1:25–1:100
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Fusion protein corresponding to a region derived from internal residues of human isocitrate dehydrogenase 3 (NAD+) beta |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1.4 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 40% glycerol |
| Contains | 0.05% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2635789 |
Product Specific Information
This antibody detects endogenous levels of total IDH3B protein.
Target Information
Isocitrate dehydrogenases catalyze the oxidative decarboxylation of isocitrate to 2-oxoglutarate. These enzymes belong to two distinct subclasses: one utilizing NAD(+) and the other NADP(+) as electron acceptors.
Five isocitrate dehydrogenases have been reported:
- Three NAD(+)-dependent forms localized to the mitochondrial matrix
- Two NADP(+)-dependent forms (one mitochondrial, one cytosolic)
NAD(+)-dependent isocitrate dehydrogenases catalyze the allosterically regulated rate-limiting step of the tricarboxylic acid cycle.
Each isozyme is a heterotetramer composed of two alpha subunits, one beta subunit, and one gamma subunit.
The IDH3B gene encodes the beta subunit of one NAD(+)-dependent isozyme, with three alternatively spliced transcript variants producing different isoforms.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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