Thermo Fisher Scientific Cytohesin 3 Polyclonal Antibody
Cytohesin 3 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody로, WB 및 IHC(P)에서 사용 가능. Human, Mouse, Rat 반응성. 고순도 항원 친화 크로마토그래피 정제. 장기 보관 시 -20°C에서 보관 권장.
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Thermo Fisher Scientific Cytohesin 3 Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to amino acids 371–400 of Human GRP1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2719096 |
Product Specific Information
The antibody was affinity-purified from rabbit antiserum by affinity chromatography using an epitope-specific immunogen. The purity is >95% (by SDS-PAGE).
Target Information
GRP1 (general receptor for phosphoinositides-1) contains a Pleckstrin homology (PH) domain and a Sec7 domain.
- The PH domain binds phosphatidylinositol 3,4,5-trisphosphate (PtdIns(3,4,5)P3).
- The Sec7 domain catalyzes guanine nucleotide exchange of ADP-ribosylation factor (ARF) proteins.
- GRP1 co-localizes with ARF6 and catalyzes GTP/GDP exchange on ARF6.
- It interacts with PtdIns(3,4,5)P3 localized to the plasma membrane and may act as a PtdIns(3,4,5)P3 receptor.
- GRP1 may regulate protein sorting and membrane trafficking through ARF interaction and control cell adhesion via integrins.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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