Thermo Fisher Scientific RAP1 Polyclonal Antibody
RAP1 단백질을 인식하는 Rabbit Polyclonal Antibody로 Western blot에 적합. Human, Mouse, Rat 반응성. 항원 친화 크로마토그래피로 정제된 고순도 항체. PBS buffer에 0.05% sodium azide 포함, 4°C 또는 -20°C 보관.
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Applications
- Western Blot (WB): 1:500–1:1,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to amino acids 220–270 of Human RAP1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2 |
| Contains | 0.05% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2719095 |
Product Specific Information
The antibody was affinity-purified from rabbit antiserum by affinity chromatography using epitope-specific immunogen, and the purity is >95% (by SDS-PAGE).
Target Information
Human Rap1 is the first identified ortholog of yeast telomeric protein scRap1, sharing three conserved sequence motifs. HRap1 is located at telomeres and affects telomere length by being recruited by TRF2 rather than directly binding to telomeric DNA. The hRap1 cDNA encodes a 399 amino acid protein (~47 kDa). hRap1 does not interact with TRF1. TRF2, a ubiquitously expressed protein, contains a Myb-related DNA binding motif and binds duplex TTAGGG repeats at telomeres. TRF2 helps maintain telomere structure and prevents senescence in primary human cells. Inhibition of TRF2 has been shown to induce apoptosis in certain mammalian cell types.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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