Thermo Fisher Scientific POT1 Polyclonal Antibody
POT1 단백질을 인식하는 Thermo Fisher Scientific의 토끼 폴리클로날 항체. Western blot에 적합하며 인간, 마우스, 랫트 반응성. 항원 친화 크로마토그래피로 정제된 고순도 항체로, 장기 보관 시 -20°C에서 안정적으로 유지됨.
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Thermo Fisher Scientific POT1 Polyclonal Antibody
Applications
- Western Blot (WB): 1:500–1:1,000
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Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Published Species | Not Applicable |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to amino acids 269–315 of Human POT1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2 |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2719094 |
Product Specific Information
The antibody was affinity-purified from rabbit antiserum by affinity chromatography using epitope-specific immunogen. The purity is >95% (by SDS-PAGE).
Target Information
POT1 is a component of the telomerase ribonucleoprotein (RNP) complex essential for chromosome end replication. It participates in the double-stranded telomeric DNA-binding TRF1 complex, regulating telomere length by cis-inhibition of telomerase. POT1 also binds single-stranded telomeric DNA, acting as a downstream effector of the TRF1 complex and transducing telomere maintenance information. It specifically binds to telomeric single-stranded 5'-TTAGGG-3' repeats and the minimal sequence 5'-TAGGGTTAG-3'. Its activity is TERT-dependent but does not increase TERT activity.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
제품 이미지
- Antigen representation: PA5-75366_POT1_Q9NUX5-1_Rabbit.svg
- PDP image: PA5-75366_POT1_Q9NUX5-1_Rabbit_PDP.jpeg
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