Thermo Fisher Scientific RGMA Polyclonal Antibody
Thermo Fisher Scientific RGMA Polyclonal Antibody는 Mouse RGM-A 단백질을 인식하는 Goat 유래 IgG 항체입니다. Western blot 및 IHC(Frozen)에 적합하며, 높은 특이성과 낮은 교차반응성을 제공합니다. 연구용으로 신경계 발달 및 신호전달 연구에 활용됩니다.
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Applications
Western Blot (WB)
- Tested Dilution: 0.1 µg/mL
Immunohistochemistry (Frozen) (IHC (F))
- Tested Dilution: 5–15 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Mouse |
| Host / Isotype | Goat / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Mouse myeloma cell line NS0-derived recombinant mouse RGM-A (Cys48–Gly421) |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 0.2 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS with 5% trehalose |
| Contains | No Preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2607236 |
Product Specific Information
In direct ELISAs, less than 15% cross-reactivity with recombinant human RGM-A and recombinant chicken RGM-A is observed, and less than 1% cross-reactivity with recombinant mouse RGM-B and RGM-C is observed.
Reconstitute at 0.2 mg/mL in sterile PBS.
Target Information
RGMA is a member of the repulsive guidance molecule (RGM) family involved in nervous system development and function. It regulates cephalic neural tube closure, inhibits neurite outgrowth and cortical neuron branching, and promotes synapse formation.
Binding to its receptor NEO1/neogenin activates the RHOA-ROCK1 signaling pathway via UNC5B-ARHGEF12/LARG-PTK2/FAK1 cascade, leading to neuronal growth cone collapse. RGMA also influences HRAS-PTK2/FAK1-AKT1 pathway for HRAS inactivation and functions as a BMP coreceptor signaling through SMAD1, SMAD5, and SMAD8.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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