Thermo Fisher Scientific LMNB2 Monoclonal Antibody (OTI2C6), TrueMAB
인간 LMNB2 단백질을 인식하는 마우스 단클론 항체. Western blot에 최적화되어 있으며, 비접합 상태로 동결건조 형태 제공. 1 mg/mL 농도로 제조되어 재구성 후 실험에 바로 사용 가능. 연구용으로 세포핵 라민 B2 단백질 분석에 적합.
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Applications
Tested Application
- Western Blot (WB): 1:2,000 dilution
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI2C6 |
| Immunogen | Full length human recombinant protein of human LMNB2 produced in HEK293T cells |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.3, with 8% trehalose |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
For reconstitution, add 100 µL distilled water to achieve a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments, perform an additional desalting step (recommended: Zeba Spin Desalting Columns, 7K MWCO, 0.5 mL, Product #89882).
Target Information
Nuclear lamins form a network of intermediate-type filaments at the nucleoplasmic side of the nuclear membrane.
Two main subtypes of nuclear lamins are recognized:
- A-type lamins: lamin A, lamin C, and lamin Adel 10 (from a single gene by alternative splicing)
- B-type lamins: lamin B1 and lamin B2 (from distinct genes)
Mutations in A-type lamins are linked to several rare but dominant genetic disorders, including:
- Emery-Dreifuss muscular dystrophy
- Dilated cardiomyopathy with conduction-system disease
- Dunnigan-type familial partial lipodystrophy
A-type lamins are associated with cell differentiation and chromatin interaction, suggesting a regulatory role in gene expression.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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