Thermo Fisher Scientific Phospho-Caspase 1 (Ser376) Polyclonal Antibody
Caspase 1의 Ser376 인산화 형태를 특이적으로 인식하는 Rabbit Polyclonal 항체. WB 및 ICC/IF에 사용 가능하며, 인간, 마우스, 랫트 반응성. 1 mg/mL 농도의 액상 형태로, -20°C에서 보관. 연구용 전용 제품.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human CASP1 (Accession P29466), corresponding to amino acid residues around phosphorylated Ser376 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Sequential chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2818410 |
Product Specific Information
This antibody detects endogenous levels of Caspase 1 only when phosphorylated at Ser376.
Target Information
Caspases are a family of cysteine proteases divided into apoptotic and inflammatory subfamilies. Unlike apoptotic caspases, inflammatory caspases are generally not involved in cell death but in immune responses to microbial pathogens. Members include caspase-1, -4, -5, and -12, which can activate proinflammatory cytokines such as IL-1β and IL-18. Caspase-1 was first identified as an IL-1β-converting enzyme and later found to be a mammalian homolog of the C. elegans cell death gene ced-3, capable of inducing apoptosis upon overexpression.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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