Thermo Fisher Scientific Phospho-C-MycThr358 (Thr358) Polyclonal Antibody

Applications and Tested Dilution

Product Specifications

Target Information

The c-Myc protein is a 62 kDa transcription factor encoded by the c-Myc gene on human chromosome 8q24. It is frequently activated in various tumor cells and plays a critical role in cellular proliferation, differentiation, apoptosis, and cell cycle progression.

Phosphorylation of c-Myc at Thr58/Ser62 by kinases such as glycogen synthase kinase 3, cyclin-dependent kinase, ERK2, and JNK is functionally associated with cell proliferation and cell cycle regulation. c-Myc is essential for vasculogenesis and angiogenesis during tumor development.

The c-Myc oncogene (p62 c-Myc) regulates normal cellular proliferation and differentiation, while deregulated expression can induce apoptosis. Antibodies against c-Myc epitopes recognize overexpressed proteins containing Myc tags fused to target proteins. Amplification of c-Myc has been observed in various human cancers, including lung, breast, and colon carcinomas. Translocations involving the c-Myc locus are characteristic of Burkitt’s lymphoma and other B-cell proliferative disorders.

Aberrant expression of c-Myc occurs in tumors of multiple origins such as colorectal, gastric, hepatic, mammary, ovarian, pulmonary, and hematopoietic neoplasms.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.