Thermo Fisher Scientific Arg3.1 Polyclonal Antibody
Rabbit polyclonal antibody against human Arg3.1, reactive with human, mouse, and rat. Suitable for IHC (Frozen) at 2–4 µg/mL. Lyophilized, protein G purified, and preservative-free. Ideal for studying synaptic plasticity and ARC protein function.
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Applications
- Immunohistochemistry (Frozen) (IHC (F)): 2–4 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to the C-terminal residues of human Arg3.1 |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 1 mg/mL |
| Purification | Protein G |
| Storage Buffer | PBS |
| Contains | No preservative |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. Glycerol (1:1) may be added for added stability. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2243111 |
Product Specific Information
The immunogenic sequence is homologous with mouse and rat Arg3.1.
Reconstitute with 500 µL of distilled water. After reconstitution, keep aliquots at -20°C for higher stability, and at 4°C with an appropriate antibacterial agent.
Target Information
ARC (Arg3.1) is a master regulator of synaptic plasticity that self-assembles into virion-like capsids, encapsulating RNAs and mediating intercellular RNA transfer in the nervous system. ARC protein is released from neurons in extracellular vesicles that transfer ARC mRNA into target cells, where it undergoes activity-dependent translation.
It is essential for long-term potentiation (LTP), long-term depression (LTD), and memory formation by regulating AMPA receptor endocytosis and maintaining neuronal homeostasis. ARC also mediates synapse elimination in the developing cerebellum and contributes to visual cortex plasticity. Additionally, ARC influences APP processing and dendritic cell migration, linking synaptic and immune regulation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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