Thermo Fisher Scientific Insulin Receptor Alpha Monoclonal Antibody (INSR/1661)
인슐린 수용체 알파 단백질을 특이적으로 인식하는 단클론 항체로, 인간 시료에 반응합니다. ELISA에 적합하며, 고순도 Protein A/G 정제 방식으로 제조되었습니다. PBS(pH 7.4) 용액 형태로 제공되며, 연구용으로만 사용 가능합니다.
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- 3643-MSM1-P1ABX
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Thermo Fisher Scientific Insulin Receptor Alpha Monoclonal Antibody (INSR/1661)
Applications
- ELISA (ELISA)
Tested Dilution: 2–4 µg/mL
Publications: -
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | INSR/1661 |
| Immunogen | Recombinant fragment of extracellular domain of human Insulin Receptor alpha (exact sequence is proprietary) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
Biological actions of insulin and IGF-1 are mediated by their respective cell surface receptor tyrosine kinases that regulate multiple signaling pathways through activation of a series of phosphorylation cascades. Insulin/IGF-1 binding to the extracellular domain leads to autophosphorylation of downstream target proteins. These receptors differ in sequence in regions that confer specificity for the designated ligand and in certain intracellular signaling domains, resulting in differences in the functional consequences of activation. Defects in IR are associated with insulin resistance syndromes, while IGF-1R defects may cause growth retardation. Both signaling cascades are also implicated in cancer development.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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