Thermo Fisher Scientific IKK epsilon Polyclonal Antibody
인간, 생쥐, 랫드 반응성을 가진 Rabbit Polyclonal 항체로 IKK epsilon 단백질 검출에 사용. Western blot, IHC, ICC/IF, ELISA 등 다양한 응용 가능. NF-kappa-B 활성화 연구에 적합하며, 액상 형태로 -20°C 보관.
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Thermo Fisher Scientific IKK epsilon Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 1:50–1:200 |
| ELISA | 1 µg/mL |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant fusion protein corresponding to amino acids 497–716 of human IKKε (NP_054721.1) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1.58 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 50% glycerol |
| Contains | 0.01% thimerosal |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2804110 |
Product Specific Information
- Positive Samples: SW480, DU145, MCF7, Mouse liver
- Cellular Location: Cytoplasm, Nucleus, PML body
- Immunogen Sequence:
SRLRTLAEVL SRCSQNITET QESLSSLNRE LVKSRDQVHE DRSIQQIQCC LDKMNFIYKQ FKKSRMRPGL GYNEEQIHKL DKVNFSHLAK RLLQVFQEEC VQKYQASLVT HGKRMRVVHE TRNHLRLVGC SVAACNTEAQ GVQESLSKLL EELSHQLLQD RAKGAQASPP PIAPYPSPTR KDLLLHMQEL CEGMKLLASD LLDNNRIIER LNRVPAPPDV
Target Information
IKBKE is an activator of nuclear factor-kappa-B. Overexpression of IKBKE has been observed in breast cancer cells, and suppression of IKBKE induces cell death. NF-kappa-B is a ubiquitous transcription factor and an essential mediator of gene expression during immune and inflammatory responses.
NF-kappa-B mediates the expression of numerous genes in response to extracellular stimuli and is associated with Ikappa-B proteins in the cytoplasm, which inhibit NF-kappa-B activity.
Ikappa-B is phosphorylated by the Ikappa-B kinase (IKK) complex containing IKK-α, IKK-β, and IKK-γ. A novel molecule in this complex, designated IKK-iota/IKK-i (IKK epsilon), is required for NF-kappa-B activation by PMA and T cell receptors but not by TNF-α or IL-1.
IKK-iota/IKK-i expression is inducible by TNF-α, IL-1, and LPS across various tissues.
Safety Information
⚠ WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.
Usage Restriction
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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