Thermo Fisher Scientific SIRT1 Polyclonal Antibody
SIRT1 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody로, WB, ICC/IF, ELISA에 사용 가능. Human 및 Mouse 반응성. 고순도 Affinity Chromatography 정제, -20°C 보관. 세포 내 에너지 대사 및 DNA 손상 반응 연구에 적합.
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Thermo Fisher Scientific SIRT1 Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunocytochemistry (ICC/IF) | 1:50–1:200 |
| ELISA | 1 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide within amino acids 201–300 of human SIRT1 (NP_0363702) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 2.68 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 50% glycerol |
| Contains | 0.05% ProClin 300 |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2804107 |
Product Specific Information
- Positive Samples: Mouse skeletal muscle, Rat thymus
- Cellular Location: Cytoplasm, Mitochondrion, Nucleus, PML body
- Immunogen sequence: SEPPKRKKRK DINTIEDA
Target Information
NAD-dependent protein deacetylase sirtuin-1 (SIRT1) links transcriptional regulation directly to intracellular energetics and coordinates multiple cellular functions such as cell cycle, response to DNA damage, metabolism, apoptosis, and autophagy.
SIRT1 modulates chromatin function through histone deacetylation and influences histone and DNA methylation, leading to transcriptional repression.
It is essential in skeletal muscle differentiation and mediates inhibitory effects on myoblast differentiation under low nutrient conditions, involving AMPK and NAMPT pathways.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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