Thermo Fisher Scientific P-cadherin Monoclonal Antibody (NCC-CAD-299)
인체 반응성 마우스 IgG1 단클론 항체로 P-cadherin(Cadherin-3) 검출에 사용. Western blot, IHC(F), Inhibition assay 등 다양한 응용 가능. 단백질 A로 정제된 동결건조 형태로 제공되며, 2–8°C에서 보관.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 5–10 µg/mL |
| Immunohistochemistry (Frozen) (IHC (F)) | 5–10 µg/mL |
| Inhibition Assays (IA) | 100 µg/mL |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | NCC-CAD-299 |
| Immunogen | Human epidermal carcinoma cell line A431 |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 0.5–1.0 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | 2–8°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
Reconstitute in distilled water to the final desired concentration.
Target Information
P-cadherin, also known as Cadherin-3, is a Type 1 cadherin protein belonging to the cadherin superfamily.
Type 1 cadherins are single-pass transmembrane proteins with five extracellular cadherin repeats and an intracellular domain that binds p120-catenin and beta-catenin.
Cadherins are calcium-dependent cell-cell adhesion glycoproteins involved in development, wound healing, cell signaling, growth, and differentiation.
P-cadherin is expressed in human fetal tissues and adult structures such as the basal layer of the epidermis, breast, prostate, ovary, cervix, hair follicle, and corneal endothelium.
It is also found in embryonic stem cells and stem cells of the mammary gland and hair follicle.
Overexpression of P-cadherin is associated with poor prognosis in breast, prostate, ovary, colon, and stomach carcinomas.
Mutations in CDH3 are linked to congenital hypotrichosis with juvenile macular dystrophy.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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