Thermo Fisher Scientific P-cadherin Monoclonal Antibody (NCC-CAD-299)

Applications

Tested Dilution

Publications

Western Blot (WB)

5-10 µg/mL

-

Immunohistochemistry (Frozen) (IHC (F))

5-10 µg/mL

-

Inhibition Assays (IA)

100 µg/mL

-

Product Specifications

Species Reactivity

Human

Host/Isotype

Mouse / IgG1

Class

Monoclonal

Type

Antibody

Clone

NCC-CAD-299

Immunogen

Human epidermal carcinoma cell line A431. if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:P-cadherin,uniProtId:P22223-1,ncbiNodeId:9606,antigenRange:1-829,antigenLength:829,antigenImageFileName:42028-100UG_P-cadherin_P22223-1_House_mouse.svg,antigenImageFileNamePDP:42028-100UG_P-cadherin_P22223-1_House_mouse_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Lyophilized

Concentration

0.5-1.0 mg/mL

Purification

Protein A

Storage buffer

PBS, pH 7.4

Contains

no preservative

Storage conditions

2-8°C

Shipping conditions

Ambient (domestic); Wet ice (international)

Product Specific Information

Reconstitute in distilled water to the final desired concentration.

Target Information

P-cadherin, also known as Cadherin-3, is a Type 1 cadherin protein that belongs to the cadherin superfamily. Type 1 cadherins are single-pass transmembrane proteins that have 5 extracellular cadherin repeats and an intracellular domain that binds p120-catenin and beta-catenin. Cadherins are calcium-dependent cell-cell adhesion glycoproteins responsible for a range of processes including development, wound healing, cell-cell signaling, cell growth and differentiation. P-cadherin is expressed in human fetal structures, and in adult tissues such as the basal layer of the epidermis, breast, prostate, ovary, cervix, hair follicle, and corneal endothelium. P-cadherin expression has also been reported on embryonic stem cells, and stem cells of the normal mammary gland, and hair follicle. Overexpression of P-cadherin has been associated with poor prognosis in breast, prostate, ovary, colon, and stomach carcinomas. Mutations in CDH3 are associated with congential hypotrichosis with juvenile macular dystrophy.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.