Thermo Fisher Scientific MASTL Polyclonal Antibody

Applications

Tested Application

• Western Blot (WB): 1:500–1:3,000

Product Specifications

Product Specific Information

This antibody detects endogenous levels of total MASTL protein.

Target Information

MASTL (microtubule associated serine/threonine kinase-like) belongs to the MAST family within the AGC Ser/Thr protein kinase group.
It promotes mitotic progression and cell cycle reentry after DNA damage. Loss of MASTL leads to defects in chromosome condensation and separation, mediated primarily by inhibition of PP2A/B55 delta.
Overexpression of MASTL is associated with cancer progression, poor patient survival, and tumor recurrence in various cancers.
Mutations at this locus are linked to autosomal dominant thrombocytopenia (thrombocytopenia-2). Alternatively spliced transcript variants have been reported.

For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.