Thermo Fisher Scientific Phospho-c-Met (Tyr1234, Tyr1235) Polyclonal Antibody
Phospho-c-Met (Tyr1234, Tyr1235) 폴리클로날 항체로, 인간 및 설치류 시료에서 c-Met 인산화 형태 검출에 적합. Western blot 및 immunoprecipitation에 사용 가능. 항원 친화 크로마토그래피로 정제된 Rabbit IgG 포맷. -20°C에서 보관.
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- PA517770
- 판매단위
- pk
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000 |
| Immunoprecipitation (IP) | 1:50 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Non-human primate, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic phosphopeptide corresponding to residues surrounding pTyr1234/1235 of human Met |
| Conjugate | Unconjugated |
| Form | Liquid |
| Purification | Antigen affinity chromatography |
| Storage Buffer | 0.01M HEPES, pH 7.5, with 0.15M NaCl, 100µg/mL BSA, 50% glycerol |
| Contains | No preservative |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_10988346 |
Product Specific Information
It is not recommended to aliquot this antibody.
Target Information
MET (c-Met) is a receptor-like tyrosine kinase whose dysregulation has been linked to many types of human malignancies. After activation by its ligand, MET interacts with PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, and STAT3. These interactions activate signaling cascades including RAS-ERK, PI3K-AKT, and PLCγ-PKC pathways. MET plays crucial roles in embryonic development (gastrulation, muscle and neuron development, angiogenesis, and kidney formation) and in adults (wound healing, organ regeneration, and tissue remodeling). Dysregulation of MET is associated with various cancers including gastric, renal, and breast cancers, making it a key target for cancer therapeutics and diagnostics.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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